Author

A. Zyryanova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Assay:proteomics· 1

Frequent Co-Authors

D. Ron· 2 shared H. P. Harding· 2 shared A. Crespillo-Casado· 1 shared A. Mafi· 1 shared A. Sakamoto· 1 shared C. Rato· 1 shared C. Sidrauski· 1 shared G. George· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiochemistry

D. Ron

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2 papers

Recent·Most cited

Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the Integrated Stress Response

Y. Yan, M. Shetty, H. P. Harding, G. George, A. Zyryanova, K. Labbe, A. Mafi, Q. Hao, C. Sidrauski, D. Ron

The paper identifies a mechanism by which eIF2γ binding to PPP1R15A enhances catalytic efficiency of the holophosphatase that terminates the integrated stress response.

bioRxiv · Dec 15, 2023Biochemistry

ISRIB blunts the integrated stress response by allosterically antagonising the inhibitory effect of phosphorylated eIF2 on eIF2B

A. Zyryanova, K. Kashiwagi, C. Rato, H. P. Harding, A. Crespillo-Casado, L. Perera, A. Sakamoto, M. Nishimoto, M. Yonemochi, M. Shirouzu, T. Ito, D. Ron

This study shows ISRIB inhibits the integrated stress response by antagonizing eIF2(P)-induced inhibition of eIF2B through allosteric effects.

bioRxiv · Sep 28, 2020Biochemistry