Author

C. Sidrauski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1

Frequent Co-Authors

A. Mafi· 1 shared A. Zyryanova· 1 shared C. Connelly· 1 shared D. B. Stetson· 1 shared D. Ron· 1 shared G. George· 1 shared H. P. Harding· 1 shared J. Henao-Mejia· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

A. Mafi

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Author profile →

2 papers

Recent·Most cited

Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the Integrated Stress Response

Y. Yan, M. Shetty, H. P. Harding, G. George, A. Zyryanova, K. Labbe, A. Mafi, Q. Hao, C. Sidrauski, D. Ron

The paper identifies a mechanism by which eIF2γ binding to PPP1R15A enhances catalytic efficiency of the holophosphatase that terminates the integrated stress response.

bioRxiv · Dec 15, 2023Biochemistry

PKR and the Integrated Stress Response drive immunopathology caused by ADAR1 mutation

M. Maurano, J. M. Snyder, C. Connelly, J. Henao-Mejia, C. Sidrauski, D. B. Stetson

This study shows that PKR and the integrated stress response drive immunopathology in ADAR1 mutation models, and an ISR inhibitor prevents disease.

bioRxiv · Nov 30, 2020 · PreprintImmunology