H. P. Harding

The paper identifies a mechanism by which eIF2γ binding to PPP1R15A enhances catalytic efficiency of the holophosphatase that terminates the integrated stress response.

The paper presents a Cryo-EM structure of the PP1c/PPP1R15A/G-actin complex that terminates the Integrated Stress Response by positioning eIF2's phosphoserine-51 at the active site.

This study shows ISRIB inhibits the integrated stress response by antagonizing eIF2(P)-induced inhibition of eIF2B through allosteric effects.

This study identifies genes and cargo receptors involved in the ER export of pathogenic α1-antitrypsin polymers using a CRISPR screen.

This study shows metformin increases GDF15 levels, which is necessary for its weight loss and insulin-sensitizing effects in both humans and mice.