Author

K. Lima

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:clinical cohort / trial· 1

Frequent Co-Authors

L. V. Riella· 2 shared T. J. Borges· 2 shared A. M. de Leal· 1 shared A. Murshid· 1 shared A. P. A. d. L. Lange· 1 shared B. J. Lang· 1 shared C. Bonorino· 1 shared D. A. Pereira-Martins· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersImmunology

L. V. Riella

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Innate extracellular Hsp70 inflammatory properties are mediated by the interaction of Siglec-E and LOX-1 receptors

T. J. Borges, K. Lima, A. Murshid, I. T. Lape, Y. Zhao, M. M. Rigo, B. J. Lang, S. S. Siddiqui, E. Hui, L. V. Riella, C. Bonorino, S. K. Calderwood

This study identifies Siglec-E and LOX-1 as receptors mediating extracellular Hsp70's inflammatory properties through their interaction on dendritic cells.

bioRxiv · Dec 1, 2023 · PreprintImmunology

Immune Response of Transplanted Kidney Tissues Assembled from Organoid Building Blocks

T. J. Borges, Y. Ganchiku, J. O. Aceves, R. van Gaal, S. G. M. Uzel, J. E. Rubins, K. Kobayashi, K. Hiratsuka, M. Tekguc, I. A. Rosales, G. T. Ribas, K. Lima, R. B. Gassen, R. Morizane, J. A. Lewis, L. V. Riella

This study transplants engineered kidney tissues made from organoid building blocks into mice with human immune cells to assess immune response and tissue integration, finding immune infiltration causes tissue injury similar to transplant rejection.

bioRxiv · Aug 26, 2023 · PreprintBioengineering

The PIP4K2 inhibitor THZ-P1-2 exhibits antileukemia activity by disruption of mitochondrial homeostasis and autophagy

K. Lima, D. A. Pereira-Martins, L. B. L. de Miranda, J. L. Coelho-Silva, G. d. S. Leandro, I. Weinhauser, R. d. C. Cavaglieri, A. M. de Leal, W. F. da Silva, A. P. A. d. L. Lange, E. D. R. P. Velloso, E. Griessinger, J. R. Hilberink, G. Huls, J. J. Schuringa, , J. A. Machado-Neto

This study shows that THZ-P1-2, a PIP4K2 inhibitor, kills leukemia cells by disrupting mitochondrial homeostasis and autophagy, with minimal effects on healthy cells.

bioRxiv · Aug 20, 2022Pharmacology & Toxicology