E. Hui

Innate extracellular Hsp70 inflammatory properties are mediated by the interaction of Siglec-E and LOX-1 receptors

This study identifies Siglec-E and LOX-1 as receptors mediating extracellular Hsp70's inflammatory properties through their interaction on dendritic cells.

A Binary RNA and DNA Self-Amplifying Platform for Next Generation Vaccines and Therapeutics

This paper introduces a binary RNA and DNA self-amplifying platform that enhances vaccine effectiveness, reduces cost, and simplifies manufacturing and distribution.

Semisynthesis of functional transmembrane proteins in GUVs

This study semisynthesizes functional transmembrane proteins in GUVs using split intein-mediated ligation, demonstrating functional retention of PD-1 in reconstituted membranes.

Molecular Features Underlying Shp1/Shp2 Discrimination by Immune Checkpoint Receptors

This study identifies the molecular mechanisms by which PD-1 and BTLA discriminate between Shp1 and Shp2 phosphatases through specific ITIM and ITSM motifs and SH2 domain interactions.

The combined influence of viscoelastic and adhesive cues on fibroblast spreading and focal adhesion formation

This study investigates how viscoelastic and adhesive cues influence fibroblast spreading and focal adhesion formation using tunable hydrogels.

Adult porcine (Sus scrofa) derived inner ear cells possessing multipotent stem/progenitor cell characteristics in in vitro cultures

This study reports the successful in vitro culture of adult porcine inner ear cells that retain stem/progenitor cell characteristics, offering a model for studying human inner ear disorders.

BTLA and PD-1 employ distinct phosphatases to differentially repress T cell signaling

This study identifies that BTLA and PD-1 use distinct phosphatases to differentially repress T cell signaling, highlighting mechanistic differences between two co-inhibitory receptors.

Spatial control of viscoelasticity in phototunable hyaluronic acid hydrogels

This study develops a hydrogel system with spatiotemporal control of viscoelasticity to mimic tissue microenvironments and shows its effects on cell behavior.

PD-L1:CD80 Heterodimer Triggers CD28 While Repressing Both PD-1 and CTLA4 Pathways

The paper identifies a molecular crosstalk where PD-L1 and CD80 form a heterodimer, blocking inhibitory pathways but preserving CD28 activation, and shows how PD-L1 blockade affects CD80 expression.

TCR-pMHC bond length controls TCR ligand discrimination

This study shows that TCR-pMHC bond length controls TCR ligand discrimination by affecting CD3ζ ITAM phosphorylation and downstream signaling.

In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase

This paper demonstrates that TCR-pMHC and PD-1-PD-L1 interactions can exclude CD45 from membrane interfaces, creating spatial organization that may regulate T cell signaling.

T cell co-stimulatory receptor CD28 is a primary target for PD-1-mediated inhibition

This study shows PD-1 inhibits T cell activation by preferentially dephosphorylating CD28 over TCR, revealing CD28 as a primary target for PD-1-mediated suppression.