TRIM5α restricts flavivirus replication by targeting the viral protease for proteasomal degradation.
A. I. Chiramel, N. Meyerson, K. McNally, R. M. Broeckel, V. Montoya, O. Mendes-Solis, S. Robertson, G. Sturdevant, K. Lubick, V. Nair, B. Youseff, R. Ireland, C. Bosio, K. Kim, J. Luban, , S. M. Best
This study shows TRIM5α restricts flavivirus replication by targeting the viral protease for proteasomal degradation, with implications for human susceptibility to emerging flaviviruses.
bioRxiv · Apr 11, 2019Microbiology