K. McNally

Design of intrinsically disordered region binding proteins

The paper designs proteins that bind intrinsically disordered regions with high affinity and specificity across diverse targets.

Structure of the Commander endosomal trafficking complex linked to X-linked intellectual disability/Ritscher-Schinzel syndrome

The paper presents the structural model of the Commander endosomal trafficking complex, identifies disease-causing mutations, and reveals its molecular function in trafficking.

Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19

The paper uses genetically diverse mice to model varied innate immune responses to SARS-CoV-2 infection, showing differences in survival, viral replication, and cytokine profiles.

A pigtailed macaque model for Kyasanur Forest disease virus and Alkhurma hemorrhagic disease virus

This paper establishes a pigtailed macaque model for KFDV and AHFV that replicates human disease symptoms and viral tropism.

High-resolution Introgressive Region Map Reveals Spatiotemporal Genome Evolution in Asian Rice Domestication

This study maps introgressive regions in Asian rice genomes to reveal spatiotemporal patterns of domestication, showing both single and multiple origins depending on genomic regions analyzed.

TRIM5α restricts flavivirus replication by targeting the viral protease for proteasomal degradation.

This study shows TRIM5α restricts flavivirus replication by targeting the viral protease for proteasomal degradation, with implications for human susceptibility to emerging flaviviruses.

Spherical Spindle Shape Promotes Perpendicular Cortical Orientation by Preventing Isometric Cortical Pulling on both Spindle Poles during C. elegans Female Meiosis

This study shows that spherical spindle shape in C. elegans female meiosis promotes perpendicular cortical orientation by preventing isometric cortical pulling on both poles and stabilizing round poles through dynein interactions.