Cell BiologybioRxiv
Regulation of Blos1 by IRE1 prevents the accumulation of Huntingtin protein aggregates
D. Bae, R. E. Jones, K. M. Piscopo…·J. Hollien
The paper shows that IRE1-mediated degradation of Blos1 prevents mHTT aggregation by promoting endosomal microautophagy, protecting cells from toxic mHTT forms.
DOI 10.1091/mbc.e22-07-0281