Unlocking the Role of Endothelial MPL Receptor and JAK2V617F Mutation: Insights into Cardiovascular Dysfunction in MPNs and CHIP
H. Zhang, N. Kafeiti, S. Lee, K. Masarik, H. Zheng, H. Zhan
This study shows that JAK2V617F mutations in endothelial cells cause cardiovascular dysfunction by promoting EndMT, and inhibiting the MPL receptor can prevent this effect.
bioRxiv · Jul 12, 2023 · PreprintCell Biology