BiophysicsScience AdvancesPeer-reviewed
Calmodulin acts as a state-dependent switch to control a cardiac potassium channel opening
P. W. Kang, A. M. Westerlund, J. Shi…·J. Cui
The paper shows CaM-VSD interactions act as a state-dependent switch to control KCNQ1 pore opening by modulating PIP2 binding and VSD-pore coupling.
DOI 10.1126/sciadv.abd6798