J. R. Silva

This study examines the electrophysiological properties of human iPSC-derived vascular smooth muscle cells and identifies cell-autonomous effects of Cantu Syndrome mutations on KATP channel function and vascular compliance.

This study investigates how arrhythmia-associated calmodulin variants affect KCNQ1 binding, membrane trafficking, and function, revealing variable impacts on cardiac ion channel regulation.

The paper identifies BC5, an allosteric agonist that modulates BK channel activation by disrupting the coupling between Ca2+ binding and pore opening.

The paper shows CaM-VSD interactions act as a state-dependent switch to control KCNQ1 pore opening by modulating PIP2 binding and VSD-pore coupling.

The paper identifies 42 phosphorylation sites on NaV1.5 channels in mouse hearts and shows their roles in regulating channel expression and gating.

This study shows that acute psychosocial stress affects attention based on subjective experience rather than direct physiological changes.