Epigenetic memory acquired during long-term EMTinduction governs the recovery to the epithelial state
P. Jain, S. Corbo, K. Mohammad, J. T. George, H. Levine, M. J. Toneff, M. K. Jolly
The paper shows that long-term EMT induction in MCF10A cells can be reversible with longer timescales, and epigenetic memory via miR-200 silencing by ZEB slows recovery to the epithelial state.
bioRxiv · Aug 23, 2022 · PreprintCancer Biology