X. Yi

Peptide Amphiphiles Hitchhike on Endogenous Biomolecules for Enhanced Cancer Imaging and Therapy

This study demonstrates that peptide amphiphile nanostructures enhance cancer imaging and therapy by hitchhiking on endogenous biomolecules to target tumors effectively.

Sex chromosome turnover in hybridizing stickleback lineages

The paper identifies an ongoing sex chromosome turnover in hybridizing stickleback lineages, where younger homomorphic sex chromosomes replace older heteromorphic ones in admixed populations.

Inhibition of the Eukaryotic Initiation Factor-2-α Kinase PERK Decreases Risk of Autoimmune Diabetes in Mice

This study shows that inhibiting PERK reduces autoimmune diabetes risk in mice by decreasing β cell immunogenicity and improving islet function.

Interferons are the key cytokines acting on pancreatic islets in type 1 diabetes

This study identifies IFN and IFNγ as key cytokines affecting pancreatic beta cells in type 1 diabetes through RNA-sequencing analysis and comparison with T1D islet signatures.

Heterogeneous genomic architecture of skeletal armour traits in sticklebacks

This study compares the genetic architecture of skeletal armor traits in two stickleback species, finding more polygenic and heterogeneous variation in nine-spined sticklebacks.

Amoeboid cells undergo durotaxis with soft end polarized NMIIA

The paper shows amoeboid cells, like T cells and neutrophils, can durotax by polarizing NMIIA towards softer substrates, and this behavior is conserved in Dictyostelium.

The cryptic step in biogeochemical Tellurium (Te) cycle: Indirect elementary Te oxidation mediated by manganese-oxidizing bacterium (MnOB)

This paper identifies a previously overlooked process where manganese-oxidizing bacteria oxidize elemental tellurium, challenging the assumption of Te0 stability in wastewater treatment.

Predicted and Experimental NMR Chemical Shifts at Variable Temperatures: The Effect of Protein Conformational Dynamics

The paper improves 15N chemical shift prediction by incorporating conformational dynamics from MD simulations, showing better agreement with experimental NMR data at different temperatures.

Contribution of protein conformational heterogeneity to NMR lineshapes at cryogenic temperatures

The paper investigates how protein conformational heterogeneity contributes to NMR lineshape broadening at cryogenic temperatures by analyzing backbone torsion angles in E. coli DHFR.

Proliferative Exhausted CD8 T Cells Exacerbate Long-lasting Anti-tumor Effects in Human Papillomavirus Positive Head and Neck Squamous Cell Carcinoma

The paper identifies a proliferative exhausted CD8+ T cell cluster in HPV-positive HNSCC that correlates with better patient survival and suggests potential therapeutic implications.

Circular RNA circGT1C1 drives gastric TIC self-renewal to initiate gastric tumorigenesis and metastasis

The paper was withdrawn due to poor experimental design and irreproducible results.

A common mechanism of temperature-sensing in thermoTRP channels

This study identifies a common mechanism for temperature sensing in TRPM8 and TRPV1 thermoTRP channels through water-protein interaction changes.

Single Particle Tracking With Compressive Sensing Using Progressive Refinement Method On Sparse Recovery (spt-PRIS)

This study introduces spt-PRIS, a new single particle tracking method that improves localization in high-density datasets with overlapping PSFs, showing effectiveness for KRAS4b subpopulation analysis.

A Tailored Approach To Study Legionella Infection Using Lattice Light Sheet Microscope (LLSM)

This study uses a modified Lattice Light Sheet Microscope to analyze Legionella pneumophila infection dynamics and morphology.

PySOFI: an open source Python package for SOFI

The paper introduces PySOFI, an open-source Python package for SOFI analysis, enabling flexible algorithm inspection, testing, modification, and extension.

Rapid Ensemble Measurement of Protein Diffusion, Probe Blinking and Photobleaching Dynamics in the Complex Cellular Space

The paper introduces a fluorescence fluctuation image correlation analysis method to measure diffusion, blinking, and photobleaching dynamics in cells, validated on simulations and live cells.

METTL9 regulates N1-histidine methylation of zinc transporters to promote tumor growth

This study identifies METTL9 as a tumor-promoting methyltransferase that methylates zinc transporters, disrupting zinc homeostasis and promoting cancer growth.

Generation of two Multipotent Mesenchymal Progenitor Cell Lines Capable of Osteogenic, Mature Osteocyte, Adipogenic, and Chondrogenic Differentiation

The paper develops two mesenchymal progenitor cell lines that can differentiate into osteogenic, adipogenic, and chondrogenic lineages and mimic in vivo responses of key regulatory genes.

Limited window for donation of convalescent plasma with high live-virus neutralizing antibodies for COVID-19 immunotherapy

The study evaluates anti-SARS-CoV-2 antibody and neutralizing titer profiles in convalescent plasma samples to determine the optimal donation window for immunotherapy.

Relationship between Anti-Spike Protein Antibody Titers and SARS-CoV-2 In Vitro Virus Neutralization in Convalescent Plasma

This study finds a strong correlation between anti-RBD and anti-ECD IgG titers and in vitro virus neutralization titers in convalescent plasma, suggesting these titers can serve as surrogates for neutralizing activity.

Cusp-artifacts in high order superresolution optical fluctuation imaging

This study identifies cusp artifacts in high-order SOFI cumulants and proposes solutions using even-order moments and dynamic range compression to improve image fidelity.

Mechanical Suppression of Breast Cancer Cell Invasion and Paracrine Signaling Requires Nucleo-Cytoskeletal Connectivity

This study shows that low-intensity vibration reduces breast cancer cell invasion and osteolytic factor secretion by mechanosensory nuclear-cytoskeletal connectivity.

PulseDIA: in-depth data independent acquisition mass spectrometry using enhanced gas phase fractionation

PulseDIA improves DIA-MS specificity and sensitivity by using gas phase fractionation, achieving higher protein identification rates in cancer proteomics.

High-throughput proteomic analysis of FFPE tissue samples facilitates tumor stratification

This study develops a proteomic workflow for FFPE tissues to stratify prostate cancer and DLBCL samples, identifying MPO as a prognostic marker and showing FFPE's utility for biomarker discovery.

Moments reconstruction and local dynamic range compression of high order Superresolution optical fluctuation imaging

This paper compares high order moments and cumulants SOFI reconstructions, showing that moments are free of cusp artifacts and enable improved resolution through deconvolution.

Microbial Cells Harboring a Mitochondrial Gene Are Capable of CO2 Capture

This study identifies a mitochondrial gene, OG1, capable of CO2 capture in engineered microorganisms, suggesting its potential for mitigating global warming through biological CO2 capture in barren lands.

Snapshots of single particles from single cells using electron microscopy

This paper combines microfluidic single cell extraction with single particle electron microscopy to study protein complexes in C. elegans embryos, revealing ribosome structures and developmental dynamics.