Author

A. K. Dube

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 8 Biochemistry· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Organism:yeast· 7 Assay:proteomics· 5 Research Focus:cell type annotation· 3 Assay:protein structure· 3 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

C. R. Landry· 9 shared I. Gagnon-Arsenault· 8 shared P. C. Despres· 3 shared A. Pageau· 2 shared C. Bedard· 2 shared D. Ascencio· 2 shared D. Bradley· 2 shared D. Evans-Yamamoto· 2 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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9 shared papersEvolutionary Biology

C. R. Landry

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Author profile →

11 papers

Recent·Most cited

Most azole antifungal resistance mutations in the drug target provide cross-resistance and carry no intrinsic fitness cost

C. Bedard, I. Gagnon-Arsenault, J. Boisvert, S. Plante, A. K. Dube, A. Pageau, J. Sharma, L. Maroc, R. S. Shapiro, C. R. Landry

The paper evaluates 4,000 Erg11 variants to determine azole resistance and fitness costs, finding 33% resistance, 88% cross-resistance, and minimal fitness cost.

bioRxiv · Dec 13, 2023 · PreprintMicrobiology

Parallel nonfunctionalization of CK1δ/ϵ kinase ohnologs following a whole-genome duplication event

D. Evans-Yamamoto, A. K. Dube, G. Saha, S. Plante, D. Bradley, I. Gagnon-Arsenault, C. R. Landry

The paper investigates the evolution of HRR25 ohnologs after a whole-genome duplication in yeast, finding that nonfunctionalization, not subfunctionalization, is the main trend.

bioRxiv · Oct 2, 2023Evolutionary Biology

Deep mutational scanning of Pneumocystis jirovecii dihydrofolate reductase reveals allosteric mechanism of resistance to an antifolate

F. D. Rouleau, A. K. Dube, I. Gagnon-Arsenault, S. Dibyachintan, A. Pageau, P. C. Despres, P. Lagüe, C. R. Landry

The paper identifies 355 resistance mutations in P. jirovecii DHFR to methotrexate using deep mutational scanning, revealing an allosteric mechanism at position F199.

bioRxiv · Sep 27, 2023 · PreprintBiochemistry

Dissection of the role of a SH3 domain in the evolution of binding preference of paralogous proteins

P. Lemieux, D. Bradley, A. K. Dube, U. Dionne, C. R. Landry

This study investigates how SH3 domains of paralogous yeast myosins evolved their binding preferences, finding that differences in interactions are not due to the SH3 domains themselves but to context-dependent factors.

bioRxiv · Mar 9, 2023 · PreprintEvolutionary Biology

Evolutionary trajectories are contingent on mitonuclear interactions

D. Biot-Pelletier, S. Bettinazzi, I. Gagnon-Arsenault, A. K. Dube, C. Bedard, T. H. M. Nguyen, H. Fiumera, S. Breton, C. Landry

This study shows that mitonuclear interactions shape evolutionary divergence in yeast populations with identical nuclear genotypes under different environmental pressures.

bioRxiv · Sep 11, 2022 · PreprintEvolutionary Biology

Epistasis between promoter activity and coding mutations shapes gene evolvability

A. F. C. Caballero, I. Gagnon-Arsenault, A. K. Dube, P. C. Despres, P. Kumar, K. Lafontaine, J. N. Pelletier, C. R. Landry

The paper shows that expression level masks the effects of coding mutations, demonstrating that expression level dictates their fitness impact.

bioRxiv · Jun 7, 2022Evolutionary Biology

Asymmetrical dose-responses shape the evolutionary trade-off between antifungal resistance and nutrient use

P. C. Despres, A. F. Cisneros Caballero, E. M. Alexander, R. Sonigara, C. Gagne-Thivierge, A. K. Dube, C. R. Landry

The paper measures amino acid substitutions in yeast Fcy1 to show a trade-off between 5-FC resistance and enzyme function, with similar patterns in Cryptococcus neoformans.

bioRxiv · Nov 29, 2021Evolutionary Biology

Rewiring the Three-Carbon Metabolism Abrogates Multiple MAPK-Induced Cellular Dysfunctions During Metabolic Disorder

A. K. Dube, N. Malenfant, F. Ladonne, A. Piano, K. Mohammad, M. Belanger, F. Begin, F. Lebel-Guay, V. I. Titorenko, Y. Bourbonnais

The paper withdraws its manuscript due to issues with lipidomic data reproducibility and reliability.

bioRxiv · Jun 30, 2021 · PreprintCell Biology

Expression attenuation as a mechanism of robustness to gene duplication in protein complexes

D. Ascencio, G. Diss, I. Gagnon-Arsenault, A. K. Dube, A. DeLuna, C. R. Landry

The paper investigates the fitness effects of gene duplication in budding yeast, finding that most protein complex subunits have minimal fitness impact, while large complexes are protected by reduced protein abundance.

bioRxiv · Jul 9, 2020 · PreprintEvolutionary Biology

The role of structural pleiotropy and regulatory evolution in the retention of heteromers of paralogs

A. Marchant, A. Cisneros, A. K. Dube, I. Gagnon-Arsenault, D. Ascencio, H. Jain, S. Aube, C. Eberlein, D. Evans-Yamamoto, N. Yachie, C. R. Landry

The paper investigates how structural pleiotropy and regulatory evolution influence the retention of heteromers formed by paralogs in budding yeast.

bioRxiv · Jul 16, 2019Evolutionary Biology

The high turnover of ribosome-associated transcripts from de novo ORFs produces gene-like characteristics available for de novo gene emergence in wild yeast populations

E. Durand, I. Gagnon-Arsenault, J. Hallin, I. Hatin, A. K. Dube, L. Nielly-Thibault, O. Namy, C. R. Landry

The paper examines de novo ORF emergence in wild yeast, finding some intergenic ORFs show gene-like characteristics despite lower translation efficiency and suggesting functional innovation potential.

bioRxiv · Dec 21, 2018Evolutionary Biology