Author

K. N. Sefton

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Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

A. F. L. Hurlstone· 1 shared B. A. Telfer· 1 shared C. Evangelou· 1 shared C. W. Wong· 1 shared D. J. Wilcock· 1 shared E. Uzuner· 1 shared H. Mole· 1 shared K. J. Williams· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

A. F. L. Hurlstone

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1 paper

Recent·Most cited

Cancer BiologyNature CommunicationsPeer-reviewedSep 26, 2023

PARP14 inhibition restores PD-1 immune checkpoint inhibitor response following IFNγ-driven adaptive resistance

C. W. Wong, C. Evangelou, K. N. Sefton…·A. F. L. Hurlstone

This study shows that PARP14 inhibition restores PD-1 checkpoint inhibitor response in IFNγ-resistant tumors by increasing T cell infiltration and reducing regulatory T cells.

DOI 10.1038/s41467-023-41737-1

mousebulk RNA-seq

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