Intranasal Nanoemulsion Adjuvanted S-2P Vaccine Demonstrates Protection in Hamsters and Induces Systemic, Cell-Mediated and Mucosal Immunity in Mice
S. Ganesan, H. Acosta, C. Brigolin, K. Orange, K. Trabbic, C. Chen, C.-E. Lien, Y.-J. Lin, M.-Y. Lin, Y.-S. Chuang, A. Fattom, V. Bitko
This study shows an intranasal nanoemulsion-adjuvanted S-2P vaccine induces strong systemic, cell-mediated, and mucosal immunity in mice and protects hamsters from SARS-CoV-2 infection.
bioRxiv · Mar 22, 2022Immunology