Author

C.-E. Lien

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Assay:proteomics· 2 Research Focus:benchmarking· 1 Organism:non-human primate· 1 Organism:rat· 1

Frequent Co-Authors

C. Chen· 4 shared M.-Y. Lin· 4 shared Y.-J. Lin· 4 shared Y.-S. Chuang· 4 shared L. T. C. Liu· 3 shared T.-Y. Kuo· 3 shared A. Fattom· 2 shared J. D. Campbell· 2 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersImmunology

C. Chen

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Intranasal Nanoemulsion Adjuvanted S-2P Vaccine Demonstrates Protection in Hamsters and Induces Systemic, Cell-Mediated and Mucosal Immunity in Mice

S. Ganesan, H. Acosta, C. Brigolin, K. Orange, K. Trabbic, C. Chen, C.-E. Lien, Y.-J. Lin, M.-Y. Lin, Y.-S. Chuang, A. Fattom, V. Bitko

This study shows an intranasal nanoemulsion-adjuvanted S-2P vaccine induces strong systemic, cell-mediated, and mucosal immunity in mice and protects hamsters from SARS-CoV-2 infection.

bioRxiv · Mar 22, 2022Immunology

Protection of Hamsters Challenged with SARS-CoV-2 after Two Doses of MVC-COV1901 Vaccine Followed by a Single Intranasal Booster with Nanoemulsion Adjuvanted S-2P Vaccine

Y.-J. Lin, M.-Y. Lin, Y.-S. Chuang, L. T. C. Liu, T.-Y. Kuo, C. Chen, S. Ganesan, A. Fattom, V. Bitko, C.-E. Lien

This study shows that a two-dose intramuscular vaccine followed by an intranasal booster provides strong protection against SARS-CoV-2 in hamsters, reducing viral load and disease symptoms.

bioRxiv · Feb 24, 2022Immunology

Protection of Hamsters Challenged with SARS-CoV-2 Variants of Concern by Two Doses of MVC-COV1901 Vaccine Followed by a Single Dose of Beta Variant Version of MVC-COV1901

T.-Y. Kuo, C.-E. Lien, Y.-J. Lin, M.-Y. Lin, C.-C. Wu, W.-H. Tang, J. D. Campbell, P. Traquina, Y.-S. Chuang, L. T. C. Liu, J. Cheng, C. Chen

This study evaluates the efficacy of a vaccine regimen using wildtype and Beta variant S-2P in hamsters against SARS-CoV-2 Delta and VoCs, showing improved neutralization and protection with a mixed-dose schedule.

bioRxiv · Sep 29, 2021 · PreprintImmunology

CpG-adjuvanted stable prefusion SARS-CoV-2 spike protein protected hamsters from SARS-CoV-2 challenge

C.-E. Lien, Y.-J. Lin, C. Chen, W.-C. Lian, T.-Y. Kuo, J. D. Campbell, P. Traquina, M.-Y. Lin, L. T. C. Liu, Y.-S. Chuang, H.-Y. Ku, C.-C. Liao, Y.-H. Chen, J.-T. Jan, C.-P. Sun, , Y.-L. Lin

This study shows that CpG-adjuvanted S-2P vaccine protected hamsters from SARS-CoV-2 infection by inducing high neutralizing antibodies and reducing viral load.

bioRxiv · Jan 7, 2021Microbiology