Clec12a tempers inflammation while restricting expansion of a colitogenic commensal
J. Round, T. Chiaro, K. Bauer, K. Ost, E. Stephen-Victor, M. Nelson, J. H. Hill, R. Bell, M. Harwood, W. Voth, T. Jackson, K. Klag, R. O'Connell, W. Z. Stephens
This study shows that Clec12a limits inflammation and prevents the expansion of a harmful commensal bacteria, Faecalibaculum rodentium, by enhancing macrophage phagocytosis.
bioRxiv · Mar 16, 2023 · PreprintImmunology