K. Bauer

Compartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage

The paper uses single-cell transcriptomics to show how two compartments in medulloblastoma are connected through a migrating precursor stage, revealing spatial and developmental links between proliferating and differentiated tumor cells.

Oncogenic RAS-Pathway Activation Drives Oncofetal Reprogramming and Creates Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia

This study identifies oncofetal reprogramming in juvenile myelomonocytic leukemia, linking RAS-pathway activation to fetal gene expression and revealing CD52 as a therapeutic target.

Clec12a tempers inflammation while restricting expansion of a colitogenic commensal

This study shows that Clec12a limits inflammation and prevents the expansion of a harmful commensal bacteria, Faecalibaculum rodentium, by enhancing macrophage phagocytosis.

HEATR5B associates with dynein-dynactin and selectively promotes motility of AP1-bound endosomal membranes

This study identifies HEATR5B as a novel dynein-dynactin interactor that promotes AP1-bound endosomal membrane motility and Golgi transport in human and Drosophila cells.

The cell-wall-localised BETA-XYLOSIDASE 4 contributes to immunity of Arabidopsis against Botrytis cinerea

BXL4 is a putative bifunctional xylosidase/arabinofuranosidase localising to the apoplast, important for immunity against the necrotrophic pathogen B. cinerea.