K. Palmer

Lipid discovery enabled by sequence statistics and machine learning

The paper uses sequence data and machine learning to identify novel substrates and lipid products of MprF in bacteria.

CRISPR-Cas inhibits plasmid transfer and immunizes bacteria against antibiotic resistance acquisition in manure

This study shows CRISPR-Cas is prevalent and effective in inhibiting plasmid transfer and antibiotic resistance acquisition in agricultural manure.

Characterization of the Oral Bacteriome of the Healthy Lewis Rat

This study characterizes the healthy oral bacteriome of male Lewis rats at two niches, finding similar bacterial groups to humans but lower diversity.

VanRS and CroRS cross-talk revealed by coevolutionary modeling regulates antibiotic resistance in VanA-type vancomycin-resistant Enterococcus faecalis

The paper identifies cross-talk between horizontally acquired and endogenous two-component systems in VanA-type vancomycin-resistant Enterococcus faecalis that contributes to antibiotic synergy.

Efficacy of plasmid-encoded CRISPR-Cas antimicrobial is affected by competitive factors found in wild Enterococcus faecalis isolates

This study evaluates the effectiveness of CRISPR-Cas antimicrobials against wild E. faecalis isolates and finds that competitive factors in these isolates reduce CRISPR-Cas efficacy.

Streptococcus pneumoniae, S. mitis, and S. oralis produce a phosphatidylglycerol-dependent, ltaS-independent glycerophosphate-linked glycolipid

This study identifies a phosphatidylglycerol-dependent, ltaS-independent glycolipid produced by S. pneumoniae, S. mitis, and S. oralis using lipidomic analysis.

Phosphatidylcholine biosynthesis in Mitis group streptococci via a host metabolite scavenging pathway

This study identifies a host metabolite scavenging pathway for phosphatidylcholine biosynthesis in Mitis group streptococci, revealing their ability to remodel membranes using human-derived metabolites.

Loss of function mutations in epaR confer resistance to phage NPV1 infection in Enterococcus faecalis OG1RF

This study identifies loss-of-function mutations in epaR as conferring resistance to phage NPV1 in E. faecalis OG1RF by blocking phage adsorption, but these mutations also increase susceptibility to daptomycin and osmotic stress.

An attenuated CRISPR-Cas system in Enterococcus faecalis permits DNA acquisition

This paper shows that Enterococcus faecalis can transiently tolerate CRISPR-Cas targeting of its own DNA, enabling DNA acquisition and genome editing.