F. Morcos

Lipid discovery enabled by sequence statistics and machine learning

The paper uses sequence data and machine learning to identify novel substrates and lipid products of MprF in bacteria.

In vivo functional phenotypes from a computational epistatic model of evolution

The paper develops a computational model to evolve functional protein variants in E. coli, showing that epistatic constraints can generate active beta-lactamase variants with enhanced activity.

VanRS and CroRS cross-talk revealed by coevolutionary modeling regulates antibiotic resistance in VanA-type vancomycin-resistant Enterococcus faecalis

The paper identifies cross-talk between horizontally acquired and endogenous two-component systems in VanA-type vancomycin-resistant Enterococcus faecalis that contributes to antibiotic synergy.

Computational Compensatory Mutation Discovery Approach: Predicting a PARP1 Variant Rescue Mutation

This paper predicts a compensatory mutation for a PARP1 variant associated with cancer using coevolutionary analysis and molecular dynamics simulations.

Divergence in dimerization and activity of primate APOBEC3C

This study identifies the molecular basis for differences in dimerization and antiviral activity of primate APOBEC3C proteins through biochemical, virological, and computational analyses.