An siRNA-guided Argonaute protein directs RNA Polymerase V to initiate DNA methylation
M. J. Sigman, K. Panda, R. Kirchner, L. L. McLain, H. Payne, J. R. Peasari, A. Y. Husbands, R. K. Slotkin, A. D. McCue
The paper shows that siRNA-guided ARGONAUTE proteins recruit RNA Polymerase V to initiate DNA methylation without preexisting methylation, challenging previous models of RdDM initiation.
bioRxiv · Aug 19, 2021Plant Biology