Genetic ablation of adhesion ligands averts rejection of allogeneic immune cells
Q. Hammer, K. Perica, H. van Ooijen, R. Mbofung, P. Momayyezi, E. Varady, K. E. Martin, Y. Pan, M. Jelcic, B. Groff, R. Abujarour, S. Krokeide, T. Lee, A. Williams, J. P. Goodridge, , K.-J. Malmberg
This study shows that deleting adhesion ligands CD54 and CD58 on allogeneic immune cells reduces NK cell rejection without impairing their anti-tumor activity.
bioRxiv · Oct 9, 2023 · PreprintImmunology