Targeting HLA-E Positive Cancers with a Novel NKG2A/C Switch Receptor
M. L. Saetersmoen, I. Kotchetkov, L. Torralba-Raga, J. Masilla-Soto, E. Sohlberg, S. Z. Krokeide, Q. Hammer, M. Sadelain, K.-J. Malmberg
This paper develops a novel chimeric A/C switch receptor to target HLA-E positive cancers, showing enhanced anti-tumor activity while avoiding off-tumor toxicity.
bioRxiv · Dec 14, 2023 · PreprintImmunology