J. P. Goodridge

The paper creates a single-cell reference map of NK cells and identifies tumor-associated states predictive of patient outcomes in melanoma and osteosarcoma.

This study shows that deleting adhesion ligands CD54 and CD58 on allogeneic immune cells reduces NK cell rejection without impairing their anti-tumor activity.

This study maps the transcriptional changes during human NK cell differentiation using single-cell RNA sequencing, identifying key gene programs and checkpoints.

The paper uses flow cytometry and single-cell RNA sequencing to show intra-lineage plasticity and functional reprogramming maintain NK cell repertoire diversity during IL-15-driven homeostasis.

The paper shows that IL-15 withdrawal induces apoptosis in NK cells by increasing BIM short splice variant expression, linked to caspase-3 activation and cell death.

This study shows that NK cell education leads to accumulation of granzyme B in secretory lysosomes, enhancing cytotoxic function through lysosomal Ca2+ signaling and TRPML1 regulation.