Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
M. L. Saetersmoen, I. Kotchetkov, L. Torralba-Raga, J. Masilla-Soto, E. Sohlberg, S. Z. Krokeide, Q. Hammer, M. Sadelain, K.-J. Malmberg
This paper develops a novel chimeric A/C switch receptor to target HLA-E positive cancers, showing enhanced anti-tumor activity while avoiding off-tumor toxicity.
bioRxiv · Dec 14, 2023 · PreprintImmunology
E. H. Ask, A. Tschan-Plessl, H. J. Hoel, A. Kolstad, H. Holte, K.-J. Malmberg
MetaGate integrates clinical metadata with high-dimensional cytometry data for interactive statistical analysis and visualization of immune cell populations in DLBCL patients.
bioRxiv · Oct 27, 2023 · PreprintImmunology
H. K. Netskar, A. Pfefferle, J. P. Goodridge, E. Sohlberg, O. Dufva, S. Teichmann, T. Clancy, a. horowitz, K.-J. Malmberg
The paper creates a single-cell reference map of NK cells and identifies tumor-associated states predictive of patient outcomes in melanoma and osteosarcoma.
bioRxiv · Oct 26, 2023Immunology
Q. Hammer, K. Perica, H. van Ooijen, R. Mbofung, P. Momayyezi, E. Varady, K. E. Martin, Y. Pan, M. Jelcic, B. Groff, R. Abujarour, S. Krokeide, T. Lee, A. Williams, J. P. Goodridge, , K.-J. Malmberg
This study shows that deleting adhesion ligands CD54 and CD58 on allogeneic immune cells reduces NK cell rejection without impairing their anti-tumor activity.
bioRxiv · Oct 9, 2023 · PreprintImmunology
B. Salome, J. P. Sfakianos, J. Daza, A. Charap, C. Hammer, R. Banchereau, A. M. Farkas, D. Geanon, G. Kelly, R. M. de Real, B. Lee, K. G. Beaumont, S. Shroff, Y. S. A. Wang, Y.-C. Wang, , Mariath
This study identifies NKG2A and HLA-E as an alternative immune checkpoint axis in bladder cancer, showing NKG2A+ CD8 T cells can bypass HLA-ABC loss through TCR-independent cytotoxicity.
bioRxiv · Mar 4, 2022 · PreprintImmunology
A. Pfefferle, H. Netskar, E. H. Ask, S. Lorenz, J. P. Goodridge, E. Sohlberg, T. Clancy, K.-J. Malmberg
This study maps the transcriptional changes during human NK cell differentiation using single-cell RNA sequencing, identifying key gene programs and checkpoints.
bioRxiv · May 7, 2019 · PreprintImmunology
A. Pfefferle, B. Jacobs, E. H. Ask, S. Lorenz, T. Clancy, J. P. Goodridge, E. Sohlberg, K.-J. Malmberg
The paper uses flow cytometry and single-cell RNA sequencing to show intra-lineage plasticity and functional reprogramming maintain NK cell repertoire diversity during IL-15-driven homeostasis.
bioRxiv · Jan 9, 2019Immunology
B. Jacobs, A. Pfefferle, D. Clement, J. P. Goodridge, M. L. Saetersmoen, S. Lorenz, M. T. Wiiger, K.-J. Malmberg
The paper shows that IL-15 withdrawal induces apoptosis in NK cells by increasing BIM short splice variant expression, linked to caspase-3 activation and cell death.
bioRxiv · Aug 17, 2018Immunology
J. P. Goodridge, B. Jacobs, M. L. Satersmoen, D. Clement, T. Clancy, E. Skarpen, A. Brech, J. Landskron, C. Grimm, A. Pfefferle, L. Meza-Zepeda, S. Lorenz, M. T. Wiiger, W. E. Louch, E. H. Ask, , K.-J. Malmberg
This study shows that NK cell education leads to accumulation of granzyme B in secretory lysosomes, enhancing cytotoxic function through lysosomal Ca2+ signaling and TRPML1 regulation.
bioRxiv · Jul 4, 2018Immunology