Cancer BiologybioRxiv
Constitutive Expression of the Progesterone Receptor Isoforms Promotes Hormone-Dependent Development of Ovarian Neoplasms
M. Wetendorf, R. Li, S.-P. Wu…·F. J. DeMayo
This study shows that overexpression of PGRB promotes ovarian tumor development in mice, while PGRA reduces tumor frequency, highlighting the role of PGR isoforms in hormone-dependent neoplasia.
DOI 10.1126/scisignal.aaz9646