Cell BiologybioRxiv
Prolonged mitosis causes separase deregulation and chromosome nondisjunction
N. Shindo, M. Otsuki, K. S. K. Uchida, T. Hirota
The paper shows prolonged metaphase causes separase activation before anaphase, leading to chromosome nondisjunction in cancer cells.
DOI 10.1016/j.celrep.2020.108652