Author

T. Hirota

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:chromatin & epigenetic regulation· 3 Approach:biophysical modeling· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. K. Michael· 1 shared A. Srivastava· 1 shared A. Toth· 1 shared A. Widger· 1 shared C. L. Partch· 1 shared C. R. Sandate· 1 shared C. Rakers· 1 shared D. de Rooij· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

A. K. Michael

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Author profile →

4 papers

Recent·Most cited

The centromere/kinetochore is assembled through CENP-C oligomerization

M. Hara, M. Ariyoshi, T. Sano, R.-s. Nozawa, S. Shinkai, S. Onami, I. Jansen, T. Hirota, T. Fukagawa

This study shows that CENP-C oligomerization is essential for centromere function by organizing centromeric chromatin and maintaining kinetochore assembly in vertebrates.

bioRxiv · Aug 17, 2022Cell Biology

Prolonged mitosis causes separase deregulation and chromosome nondisjunction

N. Shindo, M. Otsuki, K. S. K. Uchida, T. Hirota

The paper shows prolonged metaphase causes separase activation before anaphase, leading to chromosome nondisjunction in cancer cells.

bioRxiv · Jun 30, 2020Cell Biology

Protein dynamics regulate distinct biochemical properties of cryptochromes in mammalian circadian rhythms

J. L. Fribourgh, A. Srivastava, C. R. Sandate, A. K. Michael, P. L. Hsu, C. Rakers, L. T. Nguyen, M. R. Torgrimson, G. C. G. Parico, S. Tripathi, N. Zheng, G. C. Lander, T. Hirota, F. Tama, C. L. Partch

The paper identifies a dynamic loop in cryptochromes that regulates their differential binding to CLOCK:BMAL1, explaining their distinct roles in circadian rhythms.

bioRxiv · Aug 20, 2019 · PreprintBiochemistry

ATR is a multifunctional regulator of male mouse meiosis

A. Widger, S. K. Mahadevaiah, J. Lange, E. ElInati, J. Zohren, T. Hirota, M. Stanzione, O. Ojarikre, V. Maciulyte, D. de Rooij, A. Toth, S. Keeney, J. M. Turner

This study identifies ATR as a multifunctional regulator of male mouse meiosis by showing its roles in synapsis, recombination, and chromosome axis maintenance.

bioRxiv · Sep 15, 2017Cell Biology