The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains
C. Gomez Diaz, G. Jonsson, K. Schodl, L. Deszcz, A. Bestehorn, K. Eislmayr, J. Almagro, A. Kavirayani, L. M. Fennell, A. Hagelkrueys, P. Kovarik, J. M. Penninger, F. Ikeda
This study shows that the HOIL-1L NZF domain regulates immune responses by binding linear ubiquitin chains, affecting TNF and LPS-induced inflammation in mice.
bioRxiv · Apr 13, 2021Cell Biology