Cell BiologybioRxiv
The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains
C. Gomez Diaz, G. Jonsson, K. Schodl…·F. Ikeda
This study shows that the HOIL-1L NZF domain regulates immune responses by binding linear ubiquitin chains, affecting TNF and LPS-induced inflammation in mice.
DOI 10.1016/j.isci.2021.103241