Author

D. Haselbach

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:proteomics· 4 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:cryo-EM· 2 Organism:human· 2 Approach:microscopy & imaging analysis· 2 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

K. Belacic· 3 shared N. G. Brown· 3 shared A. Meinhart· 2 shared D. L. Bolhuis· 2 shared I. Grishkovskaya· 2 shared J.-M. Peters· 2 shared K. Mechtler· 2 shared P. Kukura· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiochemistry

K. Belacic

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Cryo-EM structure of the chain-elongating E3 ligase UBR5

Z. Hodakova, I. Grishkovskaya, H. L. Brunner, D. L. Bolhuis, K. Belacic, A. Schleiffer, H. Kotisch, N. G. Brown, D. Haselbach

The paper presents the cryo-EM structure of UBR5, revealing its dimeric architecture and dynamic domain movements, and identifies AKIRIN2 as an interacting protein.

bioRxiv · Nov 3, 2022 · PreprintBiochemistry

A molecular network of conserved factors keeps ribosomes dormant in the egg

K. F. Leesch, L. Lorenzo-Orts, C. Pribitzer, I. Grishkovskaya, M. Matzinger, E. Roitinger, K. Belacic, S. Kandolf, T.-Y. Lin, K. Mechtler, A. Meinhart, D. Haselbach, A. Pauli

The paper identifies conserved factors that maintain ribosome dormancy in zebrafish and Xenopus eggs and embryos, transitioning to an active state during early development.

bioRxiv · Nov 3, 2021Biochemistry

BacPROTACs mediate targeted protein degradation in bacteria

F. E. Morreale, S. Kleine, J. Leodolter, S. Ovchinnikov, J. Kley, R. Kurzbauer, D. M. Hoi, A. Meinhart, M. Hartl, D. Haselbach, M. Kaiser, T. Clausen

This paper develops BacPROTACs, small-molecule degraders that target bacterial proteins by activating the ClpC:ClpP protease, demonstrating in vivo degradation in mycobacteria.

bioRxiv · Jun 9, 2021Biochemistry

A deeply conserved miR-1 dependent regulon supports muscle cell physiology

P. Gutierrez-Perez, E. M. Santillan, T. Lendl, A. C. Schrempf, T. L. Steinacker, M. Asparuhova, M. Brandstetter, D. Haselbach, L. Cochella

This study identifies miR-1 as a regulator of mitochondria and lysosome homeostasis in muscle cells, showing its conserved role in controlling V-ATPase and DCT-1/BNIP3.

bioRxiv · Aug 31, 2020 · PreprintCell Biology

The linear ubiquitin chain assembly complex generates heterotypic ubiquitin chains

A. R. Carvajal, C. G. Diaz, A. Vogel, A. Sonn-Segev, K. Schodl, L. Deszcz, Z. Orban-Nemeth, S. Sakamoto, K. Mechtler, P. Kukura, T. Clausen, D. Haselbach, F. Ikeda

This study shows LUBAC generates heterotypic ubiquitin chains with linear and oxyester-linked branches through coordinated action of HOIP and HOIL-1L.

bioRxiv · May 27, 2020Biochemistry

Quantifying the heterogeneity of macromolecular machines by mass photometry

A. Sonn Segev, K. Belacic, T. Bodrug, G. Young, R. T. VanderLinden, B. Schulman, J. Schimpf, T. Friedrich, P. Vinh Dip, T. Schwartz, B. Bauer, J.-M. Peters, W. B. Struwe, J. L. Benesch, N. G. Brown, , P. Kukura

This paper demonstrates that mass photometry accurately quantifies sample heterogeneity with high resolution and minimal volume, outperforming negative stain electron microscopy in detecting proteasome assemblies.

bioRxiv · Dec 4, 2019Biophysics

A Protein Engineering Approach for Uncovering Cryptic Ubiquitin-binding Sites: from a Ubiquitin-Variant Inhibitor of APC/C to K48 Chain Binding

E. R. Watson, C. R. R. Grace, W. Zhang, D. J. Miller, I. F. Davidson, J. R. Prabu, S. Yu, D. L. Bolhuis, E. T. Kulko, R. Vollrath, D. Haselbach, H. Stark, J.-M. Peters, N. G. Brown, S. S. Sidhu, B. A. Schulman

The paper identifies a cryptic ubiquitin-binding site on APC/C using ubiquitin variants, revealing its preference for K48-linked chains and demonstrating a method for uncovering such sites in large complexes.

bioRxiv · Jun 12, 2019 · PreprintBiochemistry