Engineering Substrate Channeling in Assembly-Line Terpene Biosynthesis
E. S. Wenger, K. Schultz, R. Marmorstein, D. W. Christianson
This study shows that substrate channeling in PaFS occurs without a flexible linker or covalent domain linkage, and that cyclase domains associate with the prenyltransferase octamer for optimal channeling.
bioRxiv · Mar 25, 2024 · PreprintBiochemistry