Author

S. Pless

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

C. B. Borg· 1 shared C. Lund· 1 shared D. Weis· 1 shared E. P. Bennett· 1 shared H. C. Chua· 1 shared I. Galleano· 1 shared J. Andersen· 1 shared K. Schott· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiophysics

C. B. Borg

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2 papers

Recent·Most cited

Unplugging lateral fenestrations of NALCN reveals a hidden drug binding site within the pore module

K. Schott, S. G. Usher, O. Serra, V. Carnevale, S. Pless, H. C. Chua

This paper identifies a hidden drug binding site in NALCN by unplugging its lateral fenestrations and shows that 2-APB and phenytoin access the pore through distinct pathways.

bioRxiv · Apr 12, 2023 · PreprintPharmacology & Toxicology

Mechanism and site of action of big dynorphin on ASIC1a

C. B. Borg, N. Braun, S. A. Heusser, Y. Bay, D. Weis, I. Galleano, C. Lund, W. Tian, L. M. Haugaard-Kedstroem, E. P. Bennett, T. Lynagh, K. Stromgaard, J. Andersen, S. Pless

This study identifies the binding site and mechanism of big dynorphin on ASIC1a, revealing the acidic pocket as the interaction site and highlighting its potential for therapeutic development.

Proceedings of the National Academy of Sciences · Mar 12, 2020Peer-reviewedBiophysics