Human iPSC-derived Committed Cardiac Progenitors Generate Cardiac Tissue Grafts in a Swine Ischemic Cardiomyopathy Model without Triggering Ventricular Arrhythmias
A. N. Raval, E. G. Schmuck, V. Leonov, S. Roy, Y. Saito, T. Zhou, H. J. Jang, K. Wilker, J. Conklin, T. A. Hacker, C. Koonce, M. Boyer, K. Stack, E. Hebron, S. K. Nagle, , T. J. Kamp
The paper demonstrates that hiPSC-derived cardiac progenitor cells injected into swine hearts after MI form grafts that improve stress-induced contractile reserve without causing arrhythmias.
bioRxiv · Feb 14, 2024 · PreprintPathology