The Human Mitochondrial Genome Encodes for an Interferon-Responsive Host Defense Peptide
M. C. Rice, M. Imun, S. W. Jung, C. Y. Park, J. S. Kim, R. W. Lai, C. R. Barr, J. M. Son, K. Tor, E. Kim, R. J. Lu, I. Cohen, B. A. Benayoun, C. Lee
This study identifies MOTS-c, a mitochondrial-encoded host defense peptide with antibacterial and immunomodulatory functions, showing that the immune system is encoded by both nuclear and mitochondrial genomes.
bioRxiv · Mar 2, 2023 · PreprintImmunology