I. Cohen

Restriction of intercellular communication is required for organ regeneration

The paper shows that LBD genes restrict intercellular communication to enable root regeneration in plants.

The Human Mitochondrial Genome Encodes for an Interferon-Responsive Host Defense Peptide

This study identifies MOTS-c, a mitochondrial-encoded host defense peptide with antibacterial and immunomodulatory functions, showing that the immune system is encoded by both nuclear and mitochondrial genomes.

STRAINS: A Big Data Method for Classifying Cellular Response to Stimuli at the Tissue Scale

STRAINS classifies cellular responses to stimuli at the tissue scale by analyzing spatiotemporal behavior using fluorescent micrographs and machine learning.

Neuromuscular embodiment of feedback control elements in Drosophila flight

This study identifies how specific Drosophila flight muscles modulate elements of a proportional-integral controller during pitch stabilization.

MEK1/2 inhibition transiently alters the tumor immune microenvironment to enhance immunotherapy efficacy against head and neck cancer

This study shows that MEK1/2 inhibition temporarily improves the tumor immune microenvironment, enhancing immunotherapy effectiveness in head and neck cancer by reducing suppressive myeloid cells and boosting CD8+ T cell activity.

Climbing up and down binding landscapes: a high-throughput study of mutational effects in homologous protein-protein complexes

This study quantifies mutational effects on binding affinity in three homologous protease-inhibitor complexes, revealing distinct binding landscapes and epistasis patterns.

The impact of water deficit and heat stress combination on the molecular response, physiology and seed production of soybean

This study examines how soybean genotypes respond to combined water deficit and heat stress, finding that heat tolerance does not ensure tolerance to the combined stress, with reduced seed production observed in one genotype under the stress combination.

A dynamic pattern of local auxin sources is required for root regeneration

This study shows that local auxin sources are essential for root regeneration after stem cell niche removal, and their activation depends on regeneration competence factors.

Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP-9 and MMP-14

The paper engineers a specific inhibitor for MMP-9 and MMP-14 from a broad MMP inhibitor using computational design and yeast surface display, showing enhanced specificity and structural insights.