K. Tych

Hybrid lipid-block copolymer membranes enable stable reconstitution of a wide range of nanopores and robust sampling of serum

This paper demonstrates hybrid polymer-lipid membranes that enable stable nanopore sensing in human serum, showing native-like nanopore behavior and efficient analyte sampling.

The impact of ligand-induced oligomer dissociation on enzyme diffusion, directly observed at the single-molecule level

The paper investigates how ligand-induced oligomer dissociation affects enzyme diffusion using mass photometry, finding substrate-induced dissociation in some enzymes and not others.

Probing the stability and interdomain interactions in the ABC transporter OpuA, using single-molecule optical tweezers

The paper uses single-molecule optical tweezers to study the dynamics and interdomain interactions of the ABC transporter OpuA in lipid nanodiscs.

Biophysical analysis reveals autophosphorylation as an important negative regulator of LRRK2 dimerization

This study uses biophysical methods to show that autophosphorylation inhibits LRRK2 dimerization, suggesting it as a negative regulator with implications for Parkinson's disease.