Author

A. Kortholt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Organism:Drosophila· 1

Frequent Co-Authors

C. J. Gloeckner· 3 shared G. Guaitoli· 3 shared F. von Zweydorf· 2 shared F. Y. Ho· 2 shared X. Zhang· 2 shared A. Dolga· 1 shared A. Gueho· 1 shared A. J. Parnell· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersBiochemistry

C. J. Gloeckner

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Biophysical analysis reveals autophosphorylation as an important negative regulator of LRRK2 dimerization

G. Guaitoli, X. Zhang, F. Saitta, P. Miglionico, L. M. Silbermann, F. Y. Ho, F. von Zweydorf, M. Signorelli, K. Tych, D. Fessas, F. Raimondi, A. Kortholt, C. J. Gloeckner

This study uses biophysical methods to show that autophosphorylation inhibits LRRK2 dimerization, suggesting it as a negative regulator with implications for Parkinson's disease.

bioRxiv · Aug 11, 2023 · PreprintBiochemistry

Intramolecular feedback regulation of the LRRK2 Roc G domain by a LRRK2 kinase dependent mechanism

B. K. Gilsbach, F. Y. Ho, B. Riebenbauer, X. Zhang, G. Guaitoli, A. Kortholt, C. J. Gloeckner

This study identifies a kinase-dependent negative feedback mechanism regulating LRRK2 Roc G domain activity through autophosphorylation of T1343, affecting GTP hydrolysis kinetics.

bioRxiv · Jul 31, 2023 · PreprintBiochemistry

Species-specific metabolic reprogramming in human and mouse microglia during inflammatory pathway induction

A. Sabogal Guaqueta, A. Marmolejo-Garza, M. Trombetta-Lima, A. Oun, J. Hunneman, T. Chen, J. Koistinaho, S. Lehtonen, A. Kortholt, B. M. Bakker, B. J. L. Eggen, E. Boddeke, A. Dolga

This study compares metabolic reprogramming in mouse and human microglia after LPS treatment, finding species-specific changes in glycolytic gene expression.

bioRxiv · Mar 10, 2023Cell Biology

Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2

R. K. Singh, A. Soliman, G. Guaitoli, E. Störmer, F. von Zweydorf, T. Dal Maso, L. Van Rillaer, S. H. Schmidt, D. Chatterjee, E. Pardon, S. Knapp, E. J. Kennedy, J. Steyaert, F. W. Herberg, A. Kortholt, , W. Versees

This study identifies and characterizes Nanobodies that modulate LRRK2 activity through non-ATP-competitive mechanisms, offering new tools for Parkinson's disease research and therapy.

bioRxiv · Aug 30, 2021Biochemistry

Co-ordinated Ras and Rac activity shapes macropinocytic cups and enables phagocytosis of geometrically diverse bacteria

C. M. Buckley, H. Pots, A. Gueho, B. A. Phillips, B. Gilsbach, D. Traynor, A. Nikolaev, T. Soldati, A. J. Parnell, A. Kortholt, J. S. King

This study shows that RGBARG coordinates Ras and Rac activity to shape macropinocytic cups and enable phagocytosis of geometrically diverse bacteria in Dictyostelium discoideum.

bioRxiv · Oct 17, 2019Cell Biology