Author

K. Tyler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

A. Egorova· 1 shared B. Hurst· 1 shared B. Sherry· 1 shared B. Tarbet· 1 shared E. Kazakova· 1 shared J. Frost· 1 shared J. Fu· 1 shared J. S. Leser· 1 shared

Activity by Year

2021-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. Egorova

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1 paper

Recent·Most cited

Strain dependent structural effects and in vivo efficacy of enterovirus-D68 inhibitors

T. R. Lane, J. Fu, B. Sherry, B. Tarbet, B. Hurst, O. Riabova, E. Kazakova, A. Egorova, P. Clarke, J. S. Leser, J. Frost, M. Rudy, K. Tyler, T. Klose, R. J. Kuhn, , S. Ekins

This study develops a potent EV-D68 inhibitor, 11526092, showing improved in vitro potency and in vivo efficacy compared to pleconaril, with strain-dependent structural effects observed via cryo-EM.

bioRxiv · Dec 24, 2021 · PreprintPharmacology & Toxicology