Author

T. Klose

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:cryo-EM· 2 Research Focus:host-pathogen & immune response· 2 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:metagenomics· 1 Organism:mouse· 1

Frequent Co-Authors

C.-l. Chen· 2 shared J. J. G. Tesmer· 2 shared Y.-C. Yen· 2 shared A. C. S. P. Andrade· 1 shared A. Egorova· 1 shared A. Levasseur· 1 shared A. Medrano-Soto· 1 shared A. P. McGrath· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersBiophysics

C.-l. Chen

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Molecular basis for Gβγ-mediated activation ofphosphoinositide 3-kinase γ

C.-l. Chen, R. Syahirah, S. Ravala, Y.-C. Yen, T. Klose, Q. Deng, J. J. G. Tesmer

This study identifies two distinct Gβγ binding sites on PI3Kγ and shows how Gβγ activates the enzyme through conformational changes and allosteric control.

bioRxiv · May 4, 2023Biophysics

Isoform Specific Regulation of Adenylyl Cyclase 5 by Gβγ

Y.-C. Yen, Y. Li, C.-L. Chen, T. Klose, V. J. Watts, C. W. Dessauer, J. J. G. Tesmer

This study reports cryo-EM structures of AC5 with Gβγ and proposes a mechanism for its isoform-specific regulation, linking it to motor function and potential drug development.

bioRxiv · May 2, 2023 · PreprintBiophysics

Strain dependent structural effects and in vivo efficacy of enterovirus-D68 inhibitors

T. R. Lane, J. Fu, B. Sherry, B. Tarbet, B. Hurst, O. Riabova, E. Kazakova, A. Egorova, P. Clarke, J. S. Leser, J. Frost, M. Rudy, K. Tyler, T. Klose, R. J. Kuhn, , S. Ekins

This study develops a potent EV-D68 inhibitor, 11526092, showing improved in vitro potency and in vivo efficacy compared to pleconaril, with strain-dependent structural effects observed via cryo-EM.

bioRxiv · Dec 24, 2021 · PreprintPharmacology & Toxicology

A mysterious 80 nm amoeba virus with a near-complete "ORFan genome" challenges the classification of DNA viruses

P. V. M. Boratto, G. P. Oliveira, T. B. Machado, A. C. S. P. Andrade, J.-P. Baudoin, T. Klose, F. Schulz, S. Azza, P. Decloquement, E. Chabriere, P. Colson, A. Levasseur, B. La Scola, J. S. Abrahao

The paper describes the discovery of Yaravirus, a new amoeba virus with a near-complete ORFan genome, challenging existing DNA virus classifications.

Proceedings of the National Academy of Sciences · Jun 29, 2020Peer-reviewedMicrobiology

Cryo-EM Structure of OSCA1.2 from Oryza sativa: Mechanical basis of hyperosmolality-gating in Plants

K. Maity, J. Heumann, A. P. McGrath, N. J. Kopcho, P.-K. Hsu, C.-W. Lee, J. H. Mapes, D. Garza, S. Krishnan, G. P. Morgan, A. Medrano-Soto, K. J. Hendargo, T. Klose, S. D. Rees, M. H. Saier, , M. H. B. Stowell

The paper reports the cryo-EM structure of OsOSCA1.2 from rice, revealing its mechanism for sensing hyperosmolality and mediating ion permeability through structural dynamics.

bioRxiv · Dec 30, 2018Biophysics