Author

J. Frost

University of York

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Bioinformatics· 1 Immunology· 1 Pharmacology & Toxicology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Research Focus:cell type annotation· 3 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

S. Rocha· 2 shared A. Bridgeman· 1 shared A. Ciulli· 1 shared A. Egorova· 1 shared A. Townsend· 1 shared B. Hurst· 1 shared B. Sherry· 1 shared B. Tarbet· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

S. Rocha

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

3D quantification of zebrafish cerebrovascular architecture by automated image analysis of light sheet fluorescence microscopy datasets

Elisabeth Kugler, J. Frost, V. Silva, K. Plant, K. Chhabria, T. J.A. Chico, P. A. Armitage

This paper presents a 3D image analysis pipeline for quantifying zebrafish brain vasculature, showing it is robust and provides novel insights into vascular biology.

Development · Jan 10, 2022Peer-reviewedBioinformatics

Strain dependent structural effects and in vivo efficacy of enterovirus-D68 inhibitors

T. R. Lane, J. Fu, B. Sherry, B. Tarbet, B. Hurst, O. Riabova, E. Kazakova, A. Egorova, P. Clarke, J. S. Leser, J. Frost, M. Rudy, K. Tyler, T. Klose, R. J. Kuhn, , S. Ekins

This study develops a potent EV-D68 inhibitor, 11526092, showing improved in vitro potency and in vivo efficacy compared to pleconaril, with strain-dependent structural effects observed via cryo-EM.

bioRxiv · Dec 24, 2021 · PreprintPharmacology & Toxicology

VHL inhibitor binding increases intracellular level of VHL

J. Frost, S. Rocha, A. Ciulli

This study shows VHL inhibitors increase intracellular VHL levels through protein stabilization, leading to reduced HIF-1 protein and selective HIF activation.

bioRxiv · Apr 12, 2021Biochemistry

cGAMP loading enhances the immunogenicity of VLP vaccines

L. Chauveau, A. Bridgeman, T. K. Tan, R. Beveridge, J. Frost, I. Pedroza-Pacheco, T. Partridge, P. Borrow, H. Drakesmith, A. Townsend, J. Rehwinkel

This study shows that incorporating cGAMP into virus-like particles (VLPs) enhances their immunogenicity, leading to stronger T cell responses and antibody titres against HIV and influenza viruses.

bioRxiv · Jan 3, 2020 · PreprintImmunology

Hypoxia induces rapid changes to histone methylation reprogramming chromatin for the cellular response

M. Batie, J. Frost, M. Frost, J. W. Wilson, P. Schofield, S. Rocha

The paper shows hypoxia causes rapid, HIF-independent changes in histone methylation marks, linking oxygen sensing to chromatin reprogramming for cellular response.

bioRxiv · Jan 6, 2019Biochemistry

The FACT complex is required for DNA demethylation at heterochromatin during reproduction in Arabidopsis

J. Frost, M. Y. Kim, G.-T. Park, P.-H. Hsieh, M. Nakamura, S. Lin, H. Yoo, J. Choi, Y. Ikeda, T. Kinoshita, Y. Choi, D. Zilberman, R. L. Fischer

This study shows that the FACT complex facilitates DME-mediated DNA demethylation at heterochromatin during Arabidopsis reproduction by enabling access to GC-rich, nucleosome-dense regions.

bioRxiv · Sep 12, 2017Plant Biology