Oxidation of hemoproteins by Streptococcus pneumoniae collapses the cell cytoskeleton and disrupts mitochondrial respiration leading to cytotoxicity of human lung cells
A. Scasny, B. Alibayov, F. Khan, S. Rao, L. Murin, A. G. Vidal, P. Smith, L. Wei, K. S. Edwards, K. Warncke, J. E. Vidal
This study shows that Streptococcus pneumoniae produces H2O2, which oxidizes hemoproteins like hemoglobin and cytochrome c, leading to mitochondrial dysfunction and cell death in human lung cells.
bioRxiv · Jun 7, 2023 · PreprintMicrobiology