J. E. Vidal

Ultrastructural, metabolic and genetic determinants of the acquisition of macrolide resistance by Streptococcus pneumoniae

This study identifies molecular and metabolic factors that influence the acquisition of macrolide resistance in Streptococcus pneumoniae through chromosomal and ICE integration.

Heme-Mediated Selection of Encapsulated Streptococcus pneumoniae in the Lungs by Oxidative Stress

This study shows that heme from oxidized hemoglobin promotes the selection of encapsulated Streptococcus pneumoniae in the lungs, linking oxidative stress to pneumococcal pneumonia pathogenesis.

Oxidation of hemoproteins by Streptococcus pneumoniae collapses the cell cytoskeleton and disrupts mitochondrial respiration leading to cytotoxicity of human lung cells

This study shows that Streptococcus pneumoniae produces H2O2, which oxidizes hemoproteins like hemoglobin and cytochrome c, leading to mitochondrial dysfunction and cell death in human lung cells.

Oxidative reactions catalyzed by hydrogen peroxide produced by Streptococcus pneumoniae and other Streptococci Cause the Release and Degradation of Heme from Hemoglobin

Synergistic protection against secondary pneumococcal infection by human monoclonal antibodies targeting distinct epitopes

This paper demonstrates that two human monoclonal antibodies targeting distinct epitopes of pneumococcal surface protein PhtD synergistically protect against secondary pneumococcal infection in a mouse model.

Prophylactic inhibition of colonization by Streptococcus pneumoniae with the secondary bile acid metabolite deoxycholic acid

This study shows deoxycholic acid eradicates Streptococcus pneumoniae colonization in vitro and in vivo, with no observed resistance.

Hydrogen peroxide production by Streptococcus pneumoniae results in alpha-hemolysis by oxidation of oxy-hemoglobin to met-hemoglobin

This paper shows that Streptococcus pneumoniae produces hydrogen peroxide, which oxidizes oxy-hemoglobin to met-hemoglobin, causing the greenish -hemolysis halo on blood agar plates, not pneumolysin.

Captive green iguana is a reservoir of diarrheogenic Escherichia coli pathotypes

This study identifies captive green iguanas as a reservoir of diarrheogenic E. coli pathotypes with antibiotic resistance, posing a risk to human health in Latin America.