F. Khan

Memory T Cells in MHC-Deficient Humanized Mice

This study compares T cell development in humanized mice with and without murine MHC, finding that busulfan conditioning in MHC-deficient mice promotes activated T cells while irradiation favors naive T cells.

Identification of targetable vulnerabilities of PLK1-overexpressing cancers by synthetic dosage lethality

The paper identifies synthetic dosage lethality targets for PLK1-overexpressing cancers using genome-wide screens and validates key hits to show their therapeutic potential.

Bridging fungal resistance and plant growth through constitutive overexpression of Thchit42 gene in Pelargonium graveolens

This study overexpresses the Thchit42 gene in Pelargonium graveolens to enhance fungal resistance and plant growth, showing increased leaf size and oil content.

Introducing ARTiMiS: A low-cost flow imaging microscope for phytoplankton monitoring in engineered and natural environments

The paper introduces ARTiMiS, a low-cost flow imaging microscope for real-time phytoplankton monitoring, and demonstrates its performance in laboratory and full-scale cultivation systems.

Community Structure and Function During Periods of High Performance and System Upset in a Full-Scale Mixed Microalgal Wastewater Resource Recovery Facility

The paper examines microbial community dynamics in a full-scale microalgal wastewater treatment facility during stable and upset conditions, identifying key factors affecting nutrient recovery and system performance.

DNA methylation profiling identifies TBKBP1 as potent amplifier of cytotoxic activity in CMV-specific human CD8+ T cells

The paper identifies TBKBP1 as a key gene whose demethylation enhances cytotoxic activity in CMV-specific CD8+ T cells, suggesting it as a therapeutic target.

Dynamic monitoring of viral gene expression reveals rapid antiviral effects of CD8 T cells recognizing the HCMV-pp65 antigen

This study develops ARMATA, a method to measure antiviral T-cell activity against HCMV, revealing pp65 antigen recognition occurs before the late virus cycle phase.

Oxidation of hemoproteins by Streptococcus pneumoniae collapses the cell cytoskeleton and disrupts mitochondrial respiration leading to cytotoxicity of human lung cells

This study shows that Streptococcus pneumoniae produces H2O2, which oxidizes hemoproteins like hemoglobin and cytochrome c, leading to mitochondrial dysfunction and cell death in human lung cells.

RIG-I activation primes and trains innate antiviral immune memory

RIG-I activation primes and trains innate immune responses, enhancing non-specific antiviral protection in immune and non-immune cells.

Targeting IRS-1/2 in uveal melanoma inhibits in vitro cell growth, survival and migration, and in vivo tumor growth.

This study shows that NT157, an IRS-1/2 inhibitor, reduces uveal melanoma cell growth, survival, migration, and tumor growth in vivo.

Oxidative reactions catalyzed by hydrogen peroxide produced by Streptococcus pneumoniae and other Streptococci Cause the Release and Degradation of Heme from Hemoglobin

Re-convolving the compositional landscape of primary and recurrent glioblastoma reveals prognostic andtargetable tissue states

The paper identifies three tissue states in glioblastoma microenvironments using snRNAseq and spatial transcriptomics, linking them to metabolic pathways and clinical outcomes.

MR1-restricted MAIT cells from the human lung mucosal surface have distinct phenotypic, functional, and transcriptomic features that are preserved in HIV infection

This study identifies distinct phenotypic, functional, and transcriptomic features of MR1-restricted MAIT cells in the human lung mucosa, showing their preservation in HIV infection.

MicroED structure of lipid-embedded mammalian mitochondrial voltage dependent anion channel

The paper determines the near-atomic structure of mouse VDAC using MicroED after milling microcrystals grown in a lipid matrix.

Hydrogen peroxide production by Streptococcus pneumoniae results in alpha-hemolysis by oxidation of oxy-hemoglobin to met-hemoglobin

This paper shows that Streptococcus pneumoniae produces hydrogen peroxide, which oxidizes oxy-hemoglobin to met-hemoglobin, causing the greenish -hemolysis halo on blood agar plates, not pneumolysin.

Evaluating rehabilitation progress using motion features identified by machine learning

This paper uses machine learning to identify motion features for evaluating rehabilitation progress in stroke patients, finding that movement smoothness is the best measure.

The Atlas of Inflammation-Resolution (AIR)

The AIR Atlas provides a web-based resource for exploring inflammation and resolution processes, enabling bioinformatics analyses and systems biology approaches through integrated molecular interaction maps.