P. Smith

Metabolic Reprogramming by Mutant GNAS Creates an Actionable Dependency in Intraductal Papillary Mucinous Neoplasms of the Pancreas

This study shows that mutant GNAS drives a gastric metaplasia gene signature and glycolytic dependency in IPMNs, offering a therapeutic target.

The dual activity of BBK32: Implications for simultaneous inhibition of borrelial-specific antibody-dependent complement activation and fibronectin binding

This paper demonstrates that BBK32, a surface protein of Borreliella burgdorferi, simultaneously inhibits complement activation by binding C1r and binds fibronectin, aiding in immune evasion and dissemination.

The Chlamydia trachomatis secreted effector CebN targets nucleoporins and Rae1 to antagonize STAT1 nuclear import

This study identifies CebN, a Chlamydia trachomatis effector that targets nucleoporins and Rae1 to disrupt STAT1 nuclear import, aiding bacterial survival.

The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1

This study identifies ASCL1 as a critical driver of neuroendocrine lineage transition in prostate cancer using an in vivo model and spatial transcriptomics.

SCF cyclin F - EXO1 axis controls cell cycle dependent execution of double strand break repair

The paper identifies SCF cyclin F's role in regulating EXO1 degradation to control cell cycle-dependent DSB repair pathways.

The Antitumor Activities of Anti-CD47 Antibodies Require Fc-FcγR interactions

This study shows that anti-CD47 antibodies' antitumor activity depends on Fc-FcγR interactions, using a humanized mouse model to demonstrate enhanced immune responses with Fc-engineered antibodies.

Oxidation of hemoproteins by Streptococcus pneumoniae collapses the cell cytoskeleton and disrupts mitochondrial respiration leading to cytotoxicity of human lung cells

This study shows that Streptococcus pneumoniae produces H2O2, which oxidizes hemoproteins like hemoglobin and cytochrome c, leading to mitochondrial dysfunction and cell death in human lung cells.

IL-15 synergizes with CD40 agonist antibodies to induce durable immunity against bladder cancer

This study shows that combining IL-15 with CD40 agonist antibodies improves anti-tumor immunity in bladder cancer by enhancing T cell responses and memory.

Engineering and characterization of carbohydrate-binding modules to enable real-time imaging of cellulose fibrils biosynthesis in plant protoplasts

This study engineers and characterizes tandem carbohydrate-binding modules (CBMs) to enable real-time imaging of cellulose fibril biosynthesis in Arabidopsis protoplasts.

GlobalUsefulNativeTrees, a database of 14,014 tree species and their uses, supports synergies between biodiversity recovery and local livelihoods in landscape restoration

The paper introduces GlobUNT, a database of 14,014 tree species and their uses, showing Malesia has the highest useful tree species richness and diversity of uses.

Recent O-antigen diversification masks highly pathogenic STEC O104:H4

The paper identifies genomically similar, highly pathogenic STEC strains with diverse O-antigens, masking their potential risk due to rare serotypes.

Molecular landscape and functional characterization of centrosome amplification in ovarian cancer

This study identifies centrosome amplification as a common and heterogeneous feature in HGSOC, linked to CIN and treatment resistance.

Oxidative reactions catalyzed by hydrogen peroxide produced by Streptococcus pneumoniae and other Streptococci Cause the Release and Degradation of Heme from Hemoglobin

Modelling the future distribution of rare bryophytes in Scotland: is inclusion of habitat loss important?

This study uses Maxent to model future distributions of rare Scottish bryophytes under climate change, showing habitat loss significantly affects predictions.

Pseudotyped Bat Coronavirus RaTG13 is efficiently neutralised by convalescent sera from SARS-CoV-2 infected Patients

This study shows that convalescent sera from SARS-CoV-2 infected patients efficiently neutralize RaTG13, a close coronavirus relative, more effectively than SARS-CoV-2 itself.

Cholesterol Oxidation Modulates the Formation of Liquid-Ordered Domains in Model Membranes

This paper shows that 7-ketocholesterol disrupts liquid-liquid phase separation in model membranes through two mechanisms, providing a molecular explanation for its role in apoptosis.

The genomic landscape of early stage ovarian high grade serous carcinoma

This study compares genomic features of early and late stage high grade serous ovarian carcinoma, finding no unique mutations or focal copy number alterations but noting differences in ploidy and copy number signatures.

LiPyphilic: A Python toolkit for the analysis of lipid membrane simulations

LiPyphilic is a Python toolkit for analyzing lipid membrane simulations, offering tools for cholesterol flip-flop events, lipid environment classification, and trajectory transformations.

Full species-wide leaf and seed ionomic diversity of Arabidopsis thaliana

The paper quantifies the leaf and seed ionome of over 1,135 Arabidopsis thaliana accessions and identifies extreme ionomic profiles for genetic studies.

Asymmetric phospholipids impart novel biophysical properties to lipid bilayers allowing environmental adaptation

This study shows that asymmetric phospholipids in yeast membranes maintain lipid order across a wider temperature range without needing unsaturated tails or sterols.

Targeted mutation of barley (1,3;1,4)-β-glucan synthases reveals complex relationships between the storage and cell wall polysaccharide content

This study uses CRISPR/Cas9 to mutate barley Csl genes, revealing that HvCslF6 is essential for (1,3;1,4)-β-glucan synthesis while other family members affect cell wall composition and grain morphology.

Deep analysis of the USP18-dependent ISGylome and proteome unveils important roles for USP18 in tumour cell antigenicity and radiosensitivity

This study identifies novel ISGylation targets regulated by USP18, showing its role in enhancing tumour cell antigenicity and reducing radiosensitivity in CML cells.

Design to Data for mutants of β-glucosidase B from Paenibacillus polymyxa: Q22T, W123R, F155G, Y169M, W438D, V401A

The paper quantifies thermal stability and catalytic efficiency of six β-glucosidase B mutants and adds the data to a dataset to improve Rosetta algorithms for protein engineering.

Neutrophils mediate the capture of peritoneal contaminants by fat-associated lymphoid clusters of the omentum

This study identifies FALC cover cells expressing CXCL1 that recruit neutrophils to neutralize peritoneal contaminants, confirmed in human appendicitis.