L. Wei

Wide-field bond-selective fluorescence imaging: from single-molecule to cellular imaging beyond video-rate

This paper introduces WF-BonFIRE, a wide-field bond-selective fluorescence imaging technique that achieves single-molecule sensitivity and kilohertz speeds for live-cell and bacterial imaging.

Using machine learning to dissect host kinases required for Leishmania internalization and development

This study uses a kinase inhibitor screen to identify host kinases involved in Leishmania uptake and survival in macrophages, revealing both known and novel regulators.

Mapping Endothelial-Macrophage Interactions in Diabetic Vasculature: Role of TREM2 in Vascular Inflammation and Ischemic Response

This study maps endothelial-macrophage interactions in diabetic vasculature using single-cell and spatial transcriptomics, identifying TREM2 as a key driver of vascular inflammation and ischemic response in diabetes.

Screening of associated bacteria of Alexandrium catenella on affecting PSTs production and influence mechanism

The paper screens associated bacteria of Alexandrium catenella to identify those affecting PSTs production and investigates their influence on physiological and molecular processes.

PPTC7 limits mitophagy through proximal and dynamic interactions with BNIP3 and NIX

This paper shows that PPTC7 limits mitophagy by interacting with BNIP3 and NIX, promoting their proteasomal degradation through dynamic, proximal associations.

Comparison of urine proteome between obese people and normal weight people

The paper compares urine proteomes between obese and normal weight individuals to identify differential proteins associated with obesity and metabolism.

An infection and pathogenesis mouse model of SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR)

This study establishes a mouse model using GX_P2V(short_3UTR) to evaluate drug and vaccine efficacy against SARS-CoV-2.

Floral scent emission of Epiphyllum oxypetalum: identification of a novel cytosol-localized geraniol biosynthesis pathway

This study identifies a novel cytosol-localized geraniol biosynthesis pathway in Epiphyllum oxypetalum using volatilomic, transcriptomic, and biochemical approaches.

An electromyography-based multi-muscle fatigue model to investigate operational task performance

The paper develops and validates a multi-muscle fatigue model using EMG parameters and muscle ratios to predict fatigue in operational tasks.

Host kinase regulation of Plasmodium vivax dormant and replicating liver stages

This study uses kinase regression to identify host kinases regulating P. vivax liver-stage parasites, revealing variability in host dependencies across isolates that may explain field heterogeneity.

Paternal genomic resources from the YanHuang cohort suggested a Weakly-Differentiated Multi-source Admixture model for the formation of Hans founding ancestral lineages

The paper analyzes paternal genomic data from the YanHuang cohort to propose a Weakly-Differentiated Multi-source Admixture model for the formation of Han Chinese ancestral lineages.

Cell context-specific Synthetic lethality Prediction and Mechanism Analysis

This paper introduces SLWise, a deep-learning model for predicting synthetic lethal interactions in specific cellular contexts, and SLAD-CE for analyzing their mechanisms, showing improved accuracy over existing methods.

A framework for Frizzled-G protein coupling and implications to the Wnt-PCP signaling pathways

This study presents cryo-EM structures of FZD6, FZD3, and FZD1 in active and inactive states, revealing a shared activation framework and potential crosstalk between G-protein binding and Wnt-PCP signaling.

Oxidation of hemoproteins by Streptococcus pneumoniae collapses the cell cytoskeleton and disrupts mitochondrial respiration leading to cytotoxicity of human lung cells

This study shows that Streptococcus pneumoniae produces H2O2, which oxidizes hemoproteins like hemoglobin and cytochrome c, leading to mitochondrial dysfunction and cell death in human lung cells.

Deep flanking sequence engineering for efficient promoter design

This paper introduces DeepSEED, an AI framework for designing synthetic promoters by optimizing flanking sequences, showing improved performance in prokaryotic and eukaryotic systems.

The immune receptor SNC1 monitors helper NLRs targeted by a bacterial effector

The paper shows that SNC1, an immune receptor, guards ADR1-L1 and ADR1-L2 from bacterial effector suppression, enabling plant immunity through sequence diversification and a layered defense system.

Comprehensive Multi-omics Analysis Reveals the Core Role of Glycerophospholipid Metabolism in Rheumatoid Arthritis Development

This study identifies glycerophospholipid metabolism as a key factor in rheumatoid arthritis development through multi-omics analysis of gut microbiota, metabolites, and gene expression.

Development and Validation of an MRI-Derived Head-Neck Finite Element Model

This paper develops and validates a head-neck finite element model using MRI data, showing good agreement with experimental results and capturing brain dynamics previously unobserved.

IL-15 enhances functional properties and responses of CD28-negative CD4+ cytotoxic T cells expanded in Systemic lupus erythematosus

The paper identifies CD4+CD28- cytotoxic T cells in SLE patients and shows IL-15 enhances their expansion and cytotoxic function, with JAK3 inhibition blocking this effect.

Integrated single-cell sequencing analysis reveals peripheral immune landscape across the human lifespan

This study uses single-cell sequencing to analyze immune cell dynamics across human lifespan, identifying age-related changes in T cell function, cell interactions, and B cell subsets.

Senescence rewires microenvironment sensing to facilitate anti-tumor immunity

The paper shows senescent cells enhance immune surveillance by remodeling their surface proteome to better sense and respond to environmental signals like IFN-gamma.

Coenzyme A binding sites induce proximal acylation across protein families

The paper identifies that CoA-binding sites promote proximal lysine acylation in mitochondria through computational analysis and experimental validation.

Calcium determines Lactiplantibacillus plantarum intraspecies competitive fitness

This study identifies calcium as a critical nutrient for competitive fitness in Lactiplantibacillus plantarum strains, showing that calcium supplementation restores growth and competitiveness in a nutrient-limited medium.

A Chitin-Binding Protein Ultra-highly expressed in the Outer Fold of Mantle is Related to Shell Colour in Pacific Oyster Crassostrea gigas

This study identifies a chitin-binding protein, CgCBP, highly expressed in the outer fold of the mantle of Pacific oyster Crassostrea gigas, which is linked to shell pigmentation through its role in periostracum structure.

Activation of the chemokine receptor CCR1 and preferential recruitment of Gαi suppress RSV replication: implications for developing novel RSV treatment strategies

This study shows that CCR1 activation on respiratory epithelial cells suppresses RSV replication via Gi-mediated inhibition of STAT3 phosphorylation and HSP90 activity, independent of IFN-I.

Intratumoral Delivered Novel Circular mRNA Encoding Cytokines for Immune Modulation and Cancer Therapy

This paper develops a novel circular mRNA (C-RNA) platform for cancer therapy, showing it enhances anti-tumor immune responses and improves protein expression through optimized formulation.

Elucidating spatially-resolved changes in host signaling during Plasmodium liver-stage infection

This study uses digital spatial profiling to analyze host signaling changes in Plasmodium yoelii-infected hepatocytes in vivo, revealing spatial heterogeneity and immune cell responses.

A non-bactericidal cathelicidin provides prophylactic efficacy against bacterial infection by driving phagocyte influx

This study identifies a non-bactericidal cathelicidin, PopuCATH, that prevents bacterial infection by enhancing phagocyte influx and reducing inflammation without direct antimicrobial activity.

A G-lectin Receptor Kinase is a Negative Regulator of Arabidopsis Immunity Against Root-Knot Nematode Meloidogyne incognita

The paper identifies ERN1, a G-lectin receptor kinase, as a negative regulator of Arabidopsis immunity against root-knot nematodes by suppressing defense responses.

Two Types of Cinnamoyl-CoA Reductase Function Divergently in Tissue Lignification, Phenylpropanoids Flux Control, and Inter-pathway Cross-talk with Glucosinolates as Revealed in Brassica napus

This study identifies and characterizes two divergent CCR subfamilies in Brassica napus, revealing their distinct roles in lignin biosynthesis, phenylpropanoid flux, and glucosinolate interactions.