Allosteric Inhibition of the T Cell Receptor by a Designed Membrane Ligand
Y. Ye, S. Morita, K. Wilhelm, J. T. Groves, F. N. Barrera
This paper tests the allosteric model of TCR activation by designing a membrane ligand that inhibits TCR signaling, supporting the model and suggesting therapeutic applications.
bioRxiv · Aug 19, 2022Biophysics