D. Guo

First-male sperm precedence in polyandrous Spodoptera frugiperda allows sterile males induce population suppression

This study identifies first-male sperm precedence in fall armyworms and shows sterile males can suppress pest populations through sperm competition mechanisms.

Decoding the anti-aging effect of retinol in reshaping the human skin microbiome niches

This study investigates how retinol affects the human skin microbiome and its role in retinol's anti-aging effects using phenomics, metagenomics, and metabolomics.

Propiconazole and Tianfengsu Regulated the Growth, Flavor, and Nutrition of Brassica rapa by Brassinosteroid Pathway

This study examines how Propiconazole and Tianfengsu affect Brassica rapa growth, flavor, and nutrition through the brassinosteroid pathway, showing synergistic benefits when used together.

Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19

The paper identifies a potent orally bioavailable SARS-CoV-2 PLpro inhibitor with in vitro and in vivo antiviral activity against SARS-CoV-2 and related coronaviruses.

Addressing the dNTP bottleneck restricting prime editing activity

This study identifies mutations to improve prime editing efficiency in low-dNTP environments by enhancing MMLV-reverse transcriptase and reducing SAMHD1 activity.

Metagenomic analysis of individual mosquitos reveals the ecology of insect viruses

The paper analyzes the virome of 2,438 individual mosquitoes across China to reveal viral diversity, geographic hotspots, and the impact of host phylogeny on viral composition.

Using artificial intelligence to document the hidden RNA virosphere

This study uses a deep learning algorithm to discover highly divergent RNA viruses in metatranscriptomes, identifying 161,979 potential species and 180 supergroups.

The Alfin-like transcription factor GmAlfin09 regulates endoplasmic reticulum stress in soybean via a peroxidase GmPRDX6

This study identifies GmAlfin09 as a transcription factor that enhances ER stress resistance in soybean by upregulating GmPRDX6, which reduces ROS levels and maintains ER homeostasis.

KARS mediates intra-translational deposition of N6-acetyl-L-lysine in nascent proteins to contribute the acetylome in cells

The paper identifies KARS as mediating intra-translational deposition of N6-acetyl-L-lysine in nascent proteins, contributing to the acetylome in mice.

Individual bat viromes reveal the co-infection, spillover and emergence risk of potential zoonotic viruses

The study analyzes viral diversity in individual bats to assess co-infection, spillover, and zoonotic risk of potential viruses.

Formation process of the twinning β-form anhydrous guanine platelets in the scallop eyes

This study reports the formation mechanism of twinning β-form anhydrous guanine microplatelets in scallop eyes, revealing an intermediate amorphous phase and a two-step crystallization process.

Drivers of nematode diversity in forest soils across climatic zones

This study identifies climate-driven factors shaping nematode diversity in forest soils across different climatic zones.

Unconventional secretion of unglycosylated ORF8 is critical for the cytokine storm during SARS-CoV-2 infection

This study identifies unconventional secretion of unglycosylated ORF8 as critical for inducing cytokine storms during SARS-CoV-2 infection by interacting with IL17RA on macrophages.

Total virome characterizations of game animals in China reveals a spectrum of emerging viral pathogens

The paper characterizes the virome of 1725 game animals in China, identifying 71 mammalian viruses, 45 novel, and highlighting potential zoonotic risks.

Spatially-resolved transcriptomics analyses of invasive fronts in solid tumors

This study uses spatial transcriptomics to analyze invasive fronts in solid tumors, identifying immune cell enrichment, metabolic changes, and poor prognosis factors.

The adenosine analogue prodrug ATV006 is orally bioavailable and has potent preclinical efficacy against SARS-CoV-2 and its variants

Moving translational mass spectrometry imaging towards transparent and reproducible data analyses: A case study of an urothelial cancer cohort analyzed in the Galaxy framework

The paper demonstrates reproducible mass spectrometry imaging analysis of urothelial cancer tissue using the Galaxy framework, achieving high classification accuracy for tumor vs. stroma and muscle-invasive status.

NSUN2-mediated m5C methylation of IRF3 mRNA negatively regulates type I interferon responses

This study shows NSUN2-mediated m5C methylation of IRF3 mRNA reduces type I interferon responses by promoting IRF3 mRNA degradation, and NSUN2 levels decrease during viral infection to enhance antiviral immunity.

Ameliorating Emotional Attention through Modulation of Neural Oscillations with Transcranial Alternating Current Stimulation

This study tests the effect of transcranial alternating current stimulation (tACS) on emotional attention, finding increased alpha power and improved ERP responses in the active group.

Remdesivir Metabolite GS-441524 Efficiently Inhibits SARS-CoV-2 Infection in Mouse Model

This study shows that GS-441524, a metabolite of remdesivir, effectively inhibits SARS-CoV-2 in cell cultures and mice, suggesting it may contribute to remdesivir's antiviral activity.

Genome-wide screen of genomic imprinting in endosperm and population-level analysis reveal allelic variation for imprinting in flax

The paper identifies imprinted genes in flax endosperm and shows their role in intraspecific variation and domestication.

Effects of SARS-CoV-2 Mutations on Protein Structures and Intraviral Protein-Protein Interactions

This study examines how SARS-CoV-2 mutations affect protein structures and intraviral interactions, identifying mutations that cause structural changes and alter binding affinity and hot spots.

The Identification of A ROS Responsive Motif that is regulated by snoRNP in Arabidopsis

The paper identifies a ROS-responsive GGGCC motif regulated by snoRNP in Arabidopsis and shows its conservation in mouse and human genomes.

Heart Rate n-Variability (HRnV) and Its Application to Risk Stratification of Chest Pain Patients in the Emergency Department

This study introduces HRnV, a new measure of heart rate variability, and shows it improves risk prediction for adverse cardiac events in chest pain ED patients compared to traditional scores.

Abrogation of RAB27A expression transiently affects melanoma cell proliferation

This study shows that RAB27A knockdown temporarily reduces melanoma cell proliferation but has a lasting effect on invasion and metastasis.

Biocontrol of PGPR strain Bacillus amyloliquefaciens Ba168 against Phytophthora nicotianae on tobacco

This paper evaluates the biocontrol potential of PGPR strain Ba168 against tobacco black shank caused by Phytophthora nicotianae, showing it is effective but slightly less than a chemical mixture.

Heart Rate n-Variability (HRnV): A Novel Representation of Beat-to-Beat Variation in Electrocardiogram

This paper introduces HRnV, a new representation of beat-to-beat variation in ECG, and demonstrates its feasibility through simulation studies.

Interleukin-8/CXCR2 signaling regulates therapy-induced plasticity and enhances tumorigenicity in glioblastoma

This study shows IL-8 promotes cellular plasticity and therapeutic resistance in glioblastoma by altering epigenetic marks and enhancing cancer initiating cell properties.

Strong positive biodiversity-productivity relationships in a subtropical forest experiment

The paper demonstrates a strong positive biodiversity-productivity relationship in a subtropical forest experiment, showing increased productivity with species richness and complementary effects over time.

A seed resource for screening functionally redundant genes and isolation of new mutants impaired in CO2 and ABA responses

This paper generates and shares a seed library of 14,000 amiRNA-expressing Arabidopsis plants for screening functionally redundant genes, identifying new mutants in CO2 and ABA responses.