O. Schilling

Proteomic profiling of IDH-wildtype Glioblastoma Tissue and Serum uncovers prognostic Subtypes and Marker Candidates

This study identifies proteomic subtypes and recurrence patterns in IDH-wildtype glioblastoma using tissue and serum samples, revealing prognostic markers and proteomic plasticity in recurrent tumors.

Proteomic Characterization of Intrahepatic Cholangiocarcinoma Identifies Distinct Subgroups and Proteins Associated with Time-To-Recurrence

This study identifies two proteomic subgroups of intrahepatic cholangiocarcinoma with distinct time-to-recurrence rates and biological processes.

Interactors and effects of overexpressing YlxR/RpnM, a conserved RNA binding protein in cyanobacteria

This study identifies RNA-binding partners and functions of YlxR/RpnM in cyanobacteria, showing its role in RNA maturation, cell division, and nitrogen metabolism.

Alternative mRNA splicing controls the functions of the histone H3K27 demethylase UTX/KDM6A

The paper identifies extensive alternative splicing in UTX/KDM6A mRNAs that affects subcellular localization and interactions with chromatin regulatory complexes.

Targeted and Explorative Profiling of Kallikrein Proteases and Global Proteome Biology of Pancreatic Ductal Adenocarcinoma, Chronic Pancreatitis, and Normal Pancreas Highlights Disease-Specific Proteome Remodelling

This study profiles kallikrein proteases and global proteomes in PDAC, CP, and normal pancreas, identifying disease-specific proteomic changes and variants.

Changes in calpain-2 expression during glioblastoma progression predisposes tumor cells to temozolomide resistance by minimizing DNA damage and p53-dependent apoptosis

This study shows that calpain-2 expression in glioblastoma cells reduces TMZ-induced DNA damage and p53-dependent apoptosis, leading to chemoresistance.

MaxQuant and MSstats in Galaxy enable reproducible cloud-based analysis of quantitative proteomics experiments for everyone

The paper integrates MaxQuant and MSstats into Galaxy for reproducible cloud-based quantitative proteomics analysis, enabling accessible and transparent workflows for researchers.

Proteome biology of primary colorectal carcinoma and corresponding liver metastases

This study compares the proteome of primary colorectal carcinomas and their corresponding liver metastases, identifying distinct proteomic profiles and biological processes.

Moving translational mass spectrometry imaging towards transparent and reproducible data analyses: A case study of an urothelial cancer cohort analyzed in the Galaxy framework

The paper demonstrates reproducible mass spectrometry imaging analysis of urothelial cancer tissue using the Galaxy framework, achieving high classification accuracy for tumor vs. stroma and muscle-invasive status.

Discovery of a novel small protein factor involved in the coordinated degradation of phycobilisomes in cyanobacteria

The paper identifies NblD, a small protein essential for phycobilisome degradation in cyanobacteria during nitrogen starvation, showing it interacts with β-phycocyanin and is required for coordinated dismantling.

HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication

This study elucidates the allosteric mechanism of HtrA1 activation through inter-monomer communication, showing its role in proteolytic activity and disease-related pathologies.